Dr. Mounira Amor-Guéret

Dr. Mounira Amor-Guéret holds a PhD in Genetics (1982, Doctorat de 3ème cycle, Paris 6 University) and a “Doctorat d’Etat es-Sciences Naturelles” (1987, Paris 6 University). She is a Research Director at the CNRS, Coordinator of the Orsay site of the Institut Curie Research Center, and Head of the “Genetic Instability and Carcinogenesis” Team. She directed the “Genotoxic Stress and Cancer” Unit (UMR3348 CNRS/Institut Curie/Université Paris Sud-Paris Saclay) for 10 years (2010-2019). She is a member of the French National Consultative Ethics Committee for Health and Life Sciences (CCNE), appointed by the Director General of the CNRS (Official Journal, Decree of September 27th, 2016), and a member of the French National AIDS & Viral Hepatitis Council (CNS), appointed by the President of the CCNE (Official Journal, the decree of August 30th, 2019). She is also an appointed member of the Scientific Committee of the Oncology Doctoral School.

Mounira Amor-Guéret is the expert for Bloom syndrome (BS) in France. BS is a genetic disease resulting from mutations of the BLM gene with one of the strongest known correlations between chromosomal instability and a high risk of cancer. She was involved in setting up the genetic diagnosis of BS within the Genetic Oncology Department of Institut Curie Hospital. The project conducted in her team is a continuum from basic research to more translational aspects. Over the last 10 years, she and her team have shown that BS cells present a cytidine deaminase (CDA) deficiency and that CDA itself plays an essential role in maintaining genome stability. They have largely deciphered the mechanism underlying genetic instability in CDA-deficient cells, and have shown that CDA expression is downregulated in about 60% of tumors in the general population and that CDA expression status is a potential new predictive marker of susceptibility to antitumor drugs, opening up new possibilities for cancer treatment.